Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.81 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | CCR2 | P41597 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.55 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.55 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6971387 | 0.99 | HTR1A (0.79) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL6486972 | 0.86 | HTR1A (0.79) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| Hydrochloric Acid SCHEMBL6482862 | 0.85 | HTR1A (0.77) | HTR1AADRA1DADRA1AADRA1BDRD2 | |
| SCHEMBL6484702 | 0.84 | HTR1A (0.78) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL6936851 | 0.83 | HTR1A (0.69) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| Hydrochloric Acid SCHEMBL6473994 | 0.83 | HTR1A (0.77) | HTR1AADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL6484058 | 0.81 | HTR1A (0.63) | HTR1ALMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL11556531 | 0.81 | MAPK1 (0.69) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL6936848 | 0.80 | HTR1A (0.67) | HTR1AADRA1DADRA1AADRA1BLMNA | |
| SCHEMBL11860558 | 0.79 | HTR1A (0.64) | HTR1AADRA1DADRA1AADRA1BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894052-B1 | Serotonergic receptor antagonist | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2005-05-17 | — | — | US | claimed |
| EP-1000046-B1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI CHEM PHARM (CH) | 2003-11-26 | — | — | EP | claimed |
| JP-2001512111-A | — | — | 2001-08-21 | — | — | JP | claimed |
| EP-1000046-A1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI S.A. CHEMICAL and PHARMACEUTICAL COMPANY (CH) | 2000-05-17 | — | — | EP | claimed |
| WO-1999006383-A1 | PIPERAZINE DERIVATIVES ACTIVE ON THE LOWER URINARY TRACT | RECORDATI S.A., CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 1999-02-11 | — | — | WO | claimed |