Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 15/20 | 0.80 |
| ▸ | IMPDH1 | P20839 | 6/20 | 0.71 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1474383 | 0.89 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| Hydrochloric Acid SCHEMBL6485263 | 0.88 | IMPDH2 (0.98) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6499462 | 0.86 | IMPDH2 (0.80) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1473286 | 0.86 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1474188 | 0.86 | IMPDH2 (0.85) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6498795 | 0.85 | IMPDH2 (0.80) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1474040 | 0.85 | IMPDH2 (0.83) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6495844 | 0.85 | IMPDH2 (0.83) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6485360 | 0.84 | IMPDH2 (0.68) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6498962 | 0.84 | IMPDH2 (0.85) | IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867299-B2 | Inosine monophosphate dehydrogenase (IMPDH); use as immunosuppressants, anticancer agents and antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |
| EP-1127883-A2 | Oxamides as IMPDH inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-29 | — | — | EP | disclosed |