Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 13/20 | 0.70 |
| ▸ | ESR1 | P03372 | 13/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.70 |
| ▸ | TOP1 | P11387 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8179064 | 1.00 | HRAS (0.70) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL8227445 | 0.99 | HRAS (0.70) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL8188292 | 0.96 | HRAS (0.66) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL8195067 | 0.96 | HRAS (0.67) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL6491193 | 0.93 | HRAS (0.62) | HRASESR1ESR2TOP1KDM4E | |
| Tallimustine SCHEMBL62279 | 0.92 | HRAS (0.82) | HRASESR1ESR2TOP1KDM4E | |
| Tallimustine SCHEMBL1230144 | 0.91 | HRAS (0.82) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL14102116 | 0.91 | HRAS (0.80) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL8189385 | 0.90 | HRAS (0.71) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL8193689 | 0.88 | HRAS (0.77) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951951-B2 | Process for preparing distamycin derivatives | PHARMACIA ITALIA S.P.A. (IT) | 2005-10-04 | — | — | US | claimed |
| US-20040082759-A1 | Process for preparing distamycin derivatives | PHARMACIA ITALIA S.P.A. (IT) | 2004-04-29 | — | — | US | claimed |
| US-6951951-B2 | Process for preparing distamycin derivatives | PHARMACIA ITALIA S.P.A. (IT) | 2005-10-04 | — | — | US | disclosed |
| US-20040082759-A1 | Process for preparing distamycin derivatives | PHARMACIA ITALIA S.P.A. (IT) | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082759-A1 | Process for preparing distamycin derivatives | GSTP1, GSTA1, GSS | HRAS 15/4885ESR1 4086/4885ESR2 1721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.