SCHEMBL6487750

SCHEMBL6487750

O=C(NC[C@H]1CN(c2ccc(N3C[C@@H]4C(C(=O)O)[C@@H]4C3)cc2)C(=O)O1)C(F)F

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
F10 P00742 14/20 0.49
F2 P00734 2/20 0.49
ITGB3 P05106 10/20 0.47
ITGA2B P08514 10/20 0.47
PRSS1 P07477 4/20 0.47
PRSS2 P07478 4/20 0.47
PRSS3 P35030 4/20 0.47
MAOB P27338 2/20 0.45
LMNA P02545 1/20 0.45
MAOA P21397 1/20 0.45
PTGS1 P23219 1/20 0.45
CALML3 P27482 1/20 0.45
SDHA P31040 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6478553 0.90 F10 (0.48) F10F2ITGB3ITGA2BPRSS1
SCHEMBL6478558 0.90 F10 (0.48) F10F2ITGB3ITGA2BPRSS1
SCHEMBL6478137 0.89 F10 (0.52) F10F2ITGB3ITGA2BPRSS1
SCHEMBL6478702 0.87 MAOB (0.58) F10MAOBLMNAMAOAPTGS1
SCHEMBL6486390 0.86 MAOA (0.44) F10MAOBLMNAMAOAPTGS1
SCHEMBL6208779 0.86 MAOA (0.57) F10F2ITGB3ITGA2BPRSS1
SCHEMBL6478976 0.85 MAOB (0.44) F10F2ITGB3ITGA2BPRSS1
SCHEMBL6492042 0.79 MAOB (0.57) F10MAOBLMNAMAOAPTGS1
SCHEMBL6210343 0.78 MAOB (0.56) F10MAOBLMNAMAOAPTGS1
SCHEMBL6210348 0.78 MAOB (0.56) F10MAOBLMNAMAOAPTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6875784-B2 Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives PHARMACIA & UPJOHN COMPANY (US) 2005-04-05 US disclosed
US-20040127530-A1 Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives PHARMACIA & UPJOHN COMPANY 2004-07-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040127530-A1 Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives OXA1L, CYP1B1, MT-CO1 F10 1247/4885F2 1048/4885ITGB3 434/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.