Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5214973 | 0.84 | CSNK1D (0.51) | CSNK1DMAPK14CDK4MAPK10EIF2AK2 | |
| SCHEMBL5890599 | 0.76 | ALOX5 (0.38) | ADORA1CSNK1DMAPK14ALOX5CDK4 | |
| SCHEMBL21621292 | 0.74 | ADORA1 (0.44) | ADORA1CSNK1DMAPK14CDK4CCNT1 | |
| SCHEMBL29947058 | 0.74 | ADORA1 (0.44) | ADORA1CSNK1DMAPK14CDK4CCNT1 | |
| SCHEMBL5214451 | 0.74 | CSNK1D (0.51) | CSNK1DMAPK14CDK4MAPK10CDK2 | |
| SCHEMBL5726060 | 0.73 | CSNK1D (0.51) | CSNK1DMAPK14CDK4MAPK10CDK2 | |
| SCHEMBL5220849 | 0.73 | EIF2AK2 (0.50) | MAPK10EIF2AK2 | |
| SCHEMBL5890649 | 0.72 | CSNK1D (0.51) | CSNK1DMAPK14CDK4MAPK10EIF2AK2 | |
| SCHEMBL6496045 | 0.71 | CSNK1D (0.51) | CSNK1DMAPK14CDK4MAPK10CDK2 | |
| SCHEMBL5891079 | 0.71 | CSNK1D (0.50) | CSNK1DMAPK14CDK4MAPK10EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107400-A1 | Use of pyrazolopyridines as therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107400-A1 | Use of pyrazolopyridines as therapeutic compounds | QDPR, DPYD, ENTPD5 | ADORA1 1277/4885CSNK1D 2789/4885MAPK14 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.