Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | NCF1 | P14598 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2637564 | 0.81 | EGFR (0.69) | EGFRHDAC1HDAC6HDAC5PDGFRB | |
| SCHEMBL30504578 | 0.79 | EGFR (0.70) | EGFRMAPTHTTHDAC1HDAC6 | |
| SCHEMBL4649110 | 0.79 | EGFR (0.70) | EGFRMAPTHTTHDAC1HDAC6 | |
| SCHEMBL5682759 | 0.78 | EGFR (0.56) | EGFRHDAC1HDAC6HDAC5NCF1 | |
| SCHEMBL29831918 | 0.78 | EGFR (0.59) | EGFRNPC1RAB9ATDP1NCF1 | |
| SCHEMBL7140894 | 0.77 | EGFR (0.63) | EGFRNPC1RAB9AMAPTTDP1 | |
| SCHEMBL28032867 | 0.75 | HRH3 (0.62) | EGFRNPC1RAB9A | |
| SCHEMBL30241125 | 0.75 | EGFR (1.00) | EGFRNPC1RAB9APDGFRBPDGFRA | |
| SCHEMBL668493 | 0.75 | EGFR (1.00) | EGFRNPC1RAB9APDGFRBPDGFRA | |
| SCHEMBL29517021 | 0.75 | EGFR (1.00) | EGFRNPC1RAB9APDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897210-B2 | Quinazoline derivatives and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 2005-05-24 | — | — | US | disclosed |