SCHEMBL6489570

SCHEMBL6489570

CCCCCOc1ccc(Cn2c(C)nc3c(C)cc(OCc4cccc(C(=O)OC)c4)cc32)c(Cl)c1

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
BCL2 P10415 3/20 0.46
MCL1 Q07820 3/20 0.46
MRGPRX4 Q96LA9 7/20 0.44
TLR7 Q9NYK1 1/20 0.40
DCTPP1 Q9H773 1/20 0.39
PLA2G4B P0C869 1/20 0.39
GCGR P47871 1/20 0.38
PLA2G2A P14555 1/20 0.38
PPARG P37231 1/20 0.38
TDP2 O95551 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6500949 0.93 BCL2 (0.54) BCL2MCL1MRGPRX4PLA2G4BPLA2G2A
SCHEMBL6490528 0.84 DCTPP1 (0.42) MRGPRX4DCTPP1PPARG
SCHEMBL6501700 0.83 MCL1 (0.40) BCL2MCL1PPARG
SCHEMBL6502208 0.83 MCL1 (0.44) BCL2MCL1MRGPRX4PPARG
SCHEMBL6496934 0.82 MCL1 (0.54) BCL2MCL1PLA2G2A
SCHEMBL7194322 0.82 BCL2 (0.48) BCL2MCL1MRGPRX4PLA2G2A
SCHEMBL6490840 0.82 BCL2 (0.46) BCL2MCL1PLA2G2APPARG
SCHEMBL6488344 0.82 MCL1 (0.47) MCL1PLA2G4BPLA2G2APPARG
SCHEMBL6500130 0.81 DCTPP1 (0.47) BCL2MCL1DCTPP1PPARG
SCHEMBL6489915 0.80 NR4A2 (0.46) MRGPRX4DCTPP1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050014812-A1 Benzimidazole compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2005-01-20 US disclosed
WO-2004108686-A2 BENZIMIDAZOLE COMPOUNDS HAVING HYPOGLYCEMIC ACTIVITY FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2004-12-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050014812-A1 Benzimidazole compounds SLC5A1, SLC5A2, G6PD BCL2 774/4885MCL1 806/4885MRGPRX4 2443/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.