Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 5/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499829 | 1.00 | BACE1 (0.48) | BACE1HTR2BNAMPTCYP19A1GRIN2B | |
| SCHEMBL6533127 | 1.00 | BACE1 (0.48) | BACE1HTR2BNAMPTCYP19A1GRIN2B | |
| SCHEMBL6493038 | 0.90 | BACE1 (0.46) | BACE1HTR2BNAMPTGRIN2BMAPK1 | |
| SCHEMBL6491036 | 0.89 | GRIN2B (0.55) | BACE1HTR2BNAMPTGRIN2BKCNH2 | |
| SCHEMBL6493917 | 0.82 | RAB9A (0.46) | NAMPTSLC18A3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6492368 | 0.81 | GRIN2B (0.56) | BACE1HTR2BNAMPTGRIN2BKCNH2 | |
| SCHEMBL6490186 | 0.80 | HTR2B (0.43) | BACE1HTR2BNAMPTKCNH2HRH3 | |
| SCHEMBL19988362 | 0.80 | HTR2B (0.64) | BACE1HTR2BNAMPTKCNH2HRH3 | |
| SCHEMBL6499625 | 0.78 | SPR (0.43) | BACE1HTR2BMAPK1KCNH2HRH3 | |
| SCHEMBL6490937 | 0.78 | BACE1 (0.43) | BACE1HTR2BMAPK1KCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6969724-B2 | Compounds | SMITHKLINE BEECHAM-SPA (GB) | 2005-11-29 | — | — | US | disclosed |