Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 5/20 | 0.41 |
| ▸ | IKBKB | O14920 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 2/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489729 | 0.93 | ITK (0.49) | ITKTAS1R3TAS1R1HDAC6INSR | |
| SCHEMBL5753144 | 0.83 | MAPK1 (0.51) | ITKIKBKBMAPK1HDAC6INSR | |
| SCHEMBL6488334 | 0.82 | HDAC11 (0.35) | ITKKMT2ATAS1R3TAS1R1DRD2 | |
| SCHEMBL5757708 | 0.79 | JAK2 (0.49) | ITKHDAC1 | |
| SCHEMBL5755558 | 0.79 | HDAC6 (0.48) | ITKIKBKBTAS1R3TAS1R1HDAC6 | |
| SCHEMBL5756790 | 0.76 | RIPK1 (0.46) | ITKHDAC6HDAC1 | |
| SCHEMBL5756210 | 0.76 | ITK (0.54) | ITKMAPK1HDAC6INSRCCNE1 | |
| SCHEMBL5755542 | 0.76 | RIPK1 (0.44) | ITKIKBKBKMT2AHDAC6INSR | |
| SCHEMBL5759216 | 0.74 | ITK (0.51) | ITKIKBKBHDAC6 | |
| SCHEMBL5755623 | 0.74 | ITK (0.55) | ITKMAPK1INSRCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K9, MAP3K20, MAP3K19 | ITK 392/4885IKBKB 372/4885KMT2A 1158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.