Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 15/20 | 0.49 |
| ▸ | INSR | P06213 | 2/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489873 | 0.93 | ITK (0.41) | ITKINSRCCNE1CDK2TAS1R3 | |
| SCHEMBL5756210 | 0.83 | ITK (0.54) | ITKINSRCCNE1CDK2HDAC1 | |
| SCHEMBL6488334 | 0.82 | HDAC11 (0.35) | ITKTAS1R3TAS1R1 | |
| SCHEMBL5754385 | 0.79 | ITK (0.53) | ITKINSRCCNE1CDK2CASP3 | |
| SCHEMBL5754383 | 0.79 | ROCK2 (0.52) | ITKINSRCCNE1CDK2TAS1R3 | |
| SCHEMBL5816120 | 0.78 | TAS1R3 (0.47) | ITKINSRCCNE1CDK2TAS1R3 | |
| SCHEMBL5757315 | 0.76 | ITK (0.53) | ITKINSRCCNE1CDK2 | |
| SCHEMBL5753144 | 0.76 | MAPK1 (0.51) | ITKINSRCCNE1CDK2ROCK2 | |
| SCHEMBL5756552 | 0.76 | ITK (0.51) | ITKINSRCCNE1CDK2 | |
| SCHEMBL5755010 | 0.74 | ITK (0.62) | ITKINSRCCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K9, MAP3K20, MAP3K19 | ITK 392/4885INSR 579/4885CCNE1 790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.