Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 2/20 | 0.30 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.30 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489930 | 1.00 | HPGD (0.33) | HPGDLMNAHSD17B10PIM1CLK4 | |
| SCHEMBL6489539 | 0.89 | ALDH1A1 (0.40) | HPGDLMNAHSD17B10PIM1CLK4 | |
| SCHEMBL6500356 | 0.88 | PARP1 (0.36) | HPGDLMNAHSD17B10PIM1CLK4 | |
| SCHEMBL6486879 | 0.80 | MAPT (0.38) | CLK4ADRA2AADRA2BADRA2CHTT | |
| SCHEMBL6489941 | 0.80 | NISCH (0.36) | HPGDLMNAHSD17B10PIM1CLK4 | |
| SCHEMBL6487098 | 0.79 | NISCH (0.32) | ADRA2AADRA2BADRA2CHTTALDH1A1 | |
| SCHEMBL6487101 | 0.79 | NISCH (0.32) | ADRA2AADRA2BADRA2CHTTALDH1A1 | |
| SCHEMBL6495347 | 0.72 | MAPT (0.35) | HPGDLMNAHSD17B10PIM1CLK4 | |
| SCHEMBL7128314 | 0.72 | MAPT (0.35) | HPGDLMNAHSD17B10PIM1CLK4 | |
| SCHEMBL6489545 | 0.69 | KMT2A (0.40) | HPGDLMNAHSD17B10PIM1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951881-B2 | (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2005-10-04 | — | — | US | disclosed |