Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 5/20 | 0.36 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | HTR1D | P28221 | 2/20 | 0.35 |
| ▸ | HTR1B | P28222 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6489545 | 0.90 | KMT2A (0.40) | NISCHMAOAMAOBADRA1DADRA1A | |
| SCHEMBL6500360 | 0.88 | MAOA (0.37) | NISCHMAOAMAOBADRA1DADRA1A | |
| SCHEMBL6486887 | 0.81 | MAPT (0.41) | NISCHMAOAMAOBHTR1DHTR1B | |
| SCHEMBL6489930 | 0.80 | HPGD (0.33) | ADRA2APIM1CLK4ADRA2BADRA2C | |
| SCHEMBL6487105 | 0.80 | HTR1D (0.38) | NISCHMAOAMAOBHTR1DHTR1B | |
| SCHEMBL6495347 | 0.76 | MAPT (0.35) | PIM1CLK4LMNAHPGDHSD17B10 | |
| SCHEMBL7128314 | 0.76 | MAPT (0.35) | PIM1CLK4LMNAHPGDHSD17B10 | |
| SCHEMBL6491133 | 0.70 | ADRA2C (0.42) | NISCHMAOAMAOBADRA1DADRA1A | |
| SCHEMBL6488762 | 0.69 | ADRA2C (0.40) | NISCHMAOAMAOBADRA1DADRA1A | |
| SCHEMBL6489539 | 0.69 | ALDH1A1 (0.40) | PIM1CLK4LMNAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6951881-B2 | (1-substituted-indol-3-yl) alkylidenehydrazinecarboximidamide derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2005-10-04 | — | — | US | disclosed |