Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 14/20 | 0.69 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.69 |
| ▸ | HTR3B | O95264 | 5/20 | 0.69 |
| ▸ | HTR3A | P46098 | 5/20 | 0.69 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.69 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.69 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.57 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4200197 | 0.95 | CHRNA7 (0.78) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4207665 | 0.95 | CHRNA7 (0.78) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4194858 | 0.95 | CHRNA7 (0.78) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL7193258 | 0.94 | CHRNA7 (0.76) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| Hydrochloric Acid SCHEMBL7059232 | 0.94 | CHRNA7 (0.76) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6499033 | 0.83 | CHRNA7 (0.72) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4201891 | 0.82 | CHRNA7 (0.79) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4207143 | 0.82 | CHRNA7 (0.79) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL4201895 | 0.82 | CHRNA7 (0.79) | CHRNA7HTR3EHTR3BHTR3AHTR3D | |
| SCHEMBL6806889 | 0.82 | CHRNA7 (1.00) | CHRNA7HTR3EHTR3BHTR3AHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919359-B2 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PFIZER INC (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | MALT1, WFS1, NR5A1 | CHRNA7 1097/4885HTR3E 3516/4885HTR3B 2561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.