Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.45 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MLKL | Q8NB16 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6757814 | 0.90 | MEN1 (0.44) | PDE10AHTTMEN1KMT2AKDM4E | |
| SCHEMBL6489386 | 0.71 | MEN1 (0.49) | PDE10AHTTMEN1KMT2AMAPK1 | |
| SCHEMBL1870245 | 0.67 | ATM (0.50) | HTTMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL6490440 | 0.66 | PDE10A (0.45) | PDE10AHTTMEN1KMT2AMAPK1 | |
| SCHEMBL6493237 | 0.65 | PDE10A (0.54) | PDE10AHTTMEN1KMT2AMAPK1 | |
| SCHEMBL10015630 | 0.65 | GPR3 (0.53) | PDE10ADHODHHTTMEN1KMT2A | |
| SCHEMBL6670749 | 0.64 | LMNA (0.41) | HTTMEN1KMT2AMAPK1KDM4E | |
| SCHEMBL13957825 | 0.64 | PDE10A (1.00) | PDE10ADHODHHTTMEN1KMT2A | |
| SCHEMBL4004067 | 0.63 | HPGD (0.52) | MAPK1TSHRGAAALDH1A1NPSR1 | |
| SCHEMBL3122185 | 0.63 | MAPK1 (0.45) | PDE10ADHODHMEN1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6962938-B2 | Spiro-cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-11-08 | — | — | US | disclosed |