Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16002483 | 0.86 | GPR119 (0.47) | GPR119USP30JAK2JAK1KDM4E | |
| SCHEMBL14039529 | 0.85 | GPR119 (0.53) | GPR119USP30JAK2JAK1KDM4E | |
| SCHEMBL1841361 | 0.79 | GPR119 (0.43) | GPR119USP30JAK2JAK1KDM4E | |
| SCHEMBL1842300 | 0.79 | GPR119 (0.43) | GPR119USP30JAK2JAK1KDM4E | |
| SCHEMBL13944382 | 0.75 | KDM4E (0.43) | GPR119USP30JAK2JAK1KDM4E | |
| SCHEMBL14640733 | 0.75 | GPR119 (0.42) | GPR119USP30JAK2JAK1KDM4E | |
| SCHEMBL30681428 | 0.75 | BCHE (0.46) | GPR119KDM4EPKMRORC | |
| SCHEMBL1841901 | 0.74 | JAK2 (0.41) | GPR119USP30JAK2JAK1MEN1 | |
| SCHEMBL1844685 | 0.74 | JAK2 (0.41) | GPR119USP30JAK2JAK1MEN1 | |
| SCHEMBL10127911 | 0.74 | USP30 (0.50) | USP30MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849619-B2 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-01 | — | — | US | disclosed |