Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6491320 | 0.98 | HSD11B1 (0.51) | HSD11B1SMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL4239672 | 0.84 | HSD11B1 (0.68) | HSD11B1SMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL15873720 | 0.83 | HSD11B1 (0.49) | HSD11B1SMN1; SMN2ALDH1A1POLBL3MBTL1 | |
| SCHEMBL17761311 | 0.83 | HSD11B1 (0.71) | HSD11B1SLC6A3SLC6A4 | |
| SCHEMBL12836588 | 0.83 | SLC6A4 (0.59) | HSD11B1ALDH1A1SLC6A3SLC6A4 | |
| SCHEMBL15862926 | 0.83 | HSD11B1 (0.41) | HSD11B1SMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL4866308 | 0.82 | DPP4 (0.58) | HSD11B1SMN1; SMN2ALDH1A1MAPK1LMNA | |
| SCHEMBL12836593 | 0.81 | SLC6A3 (0.62) | HSD11B1ALDH1A1SLC6A3SLC6A4 | |
| SCHEMBL17761201 | 0.81 | HSD11B1 (0.51) | HSD11B1ALDH1A1L3MBTL1SLC6A3SLC6A4 | |
| SCHEMBL17761297 | 0.81 | HSD11B1 (0.73) | HSD11B1SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | BAYER HEALTHCARE AG (DE) | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234096-A1 | Tetrahydroisoquinoline derivatives | PPARD, PPARG, PPARA | HSD11B1 213/4885SMN1; SMN2 4874/4885ALDH1A1 2218/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.