Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 6/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4448873 | 0.97 | SMN1; SMN2 (0.42) | SMN1; SMN2NPC1MAPK14KEAP1NFE2L2 | |
| Hydrochloric Acid SCHEMBL6321478 | 0.96 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1MAPK14KEAP1NFE2L2 | |
| SCHEMBL4454362 | 0.94 | MEN1 (0.39) | KEAP1NFE2L2KMT2AMEN1SLC9A1 | |
| Hydrochloric Acid SCHEMBL6315706 | 0.93 | MEN1 (0.38) | SMN1; SMN2KEAP1NFE2L2KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6314734 | 0.89 | MAPK14 (0.41) | SMN1; SMN2NPC1MAPK14KEAP1NFE2L2 | |
| SCHEMBL4454473 | 0.87 | TP53 (0.40) | MAPK14KEAP1NFE2L2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL6312762 | 0.86 | TP53 (0.39) | SMN1; SMN2MAPK14KEAP1NFE2L2KMT2A | |
| SCHEMBL4449007 | 0.86 | SLC9A1 (0.39) | KEAP1NFE2L2KMT2AMEN1SLC9A1 | |
| Hydrochloric Acid SCHEMBL6313083 | 0.85 | SLC9A1 (0.39) | SMN1; SMN2KEAP1NFE2L2KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL6321504 | 0.84 | KEAP1 (0.40) | SMN1; SMN2KEAP1NFE2L2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050171049-A1 | Compounds for the treatment of ischemia | DENINNO MICHAEL P (US) | 2005-08-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050171049-A1 | Compounds for the treatment of ischemia | TNNI3, ADRB3, TBXA2R | SMN1; SMN2 1665/4885NPC1 3299/4885MAPK14 4288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.