Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | UBE2N | P61088 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6488118 | 0.82 | TYK2 (0.45) | MAPTSMN1; SMN2TP53AKR1C3AKR1C2 | |
| SCHEMBL6487994 | 0.81 | MEN1 (0.46) | MAPTSMN1; SMN2KMT2ANPSR1MEN1 | |
| SCHEMBL6480619 | 0.80 | KMT2A (0.44) | MAPTSMN1; SMN2KMT2ANPSR1KDM4E | |
| SCHEMBL6480891 | 0.80 | NPSR1 (0.50) | SMN1; SMN2MAOBMAOAUSP2NPSR1 | |
| SCHEMBL6492262 | 0.80 | NPSR1 (0.47) | SMN1; SMN2MAOBMAOAKMT2APOLB | |
| SCHEMBL6482059 | 0.79 | KDM4E (0.38) | MAPTTHRBAKR1C3AKR1C2KMT2A | |
| SCHEMBL6481059 | 0.79 | NPSR1 (0.49) | SMN1; SMN2MAOBMAOAUSP2NPSR1 | |
| SCHEMBL6492628 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53KMT2AUSP2NPSR1 | |
| SCHEMBL6491898 | 0.76 | RAB9A (0.55) | MAPTSMN1; SMN2KMT2ATDP1MEN1 | |
| SCHEMBL6480163 | 0.75 | AKR1C3 (0.44) | MAPTAKR1C3AKR1C2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050215614-A1 | Substituted indoles and their use as hcv inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215614-A1 | Substituted indoles and their use as hcv inhibitors | IDO1, IDO2, HAVCR2 | MAPT 3587/4885SMN1; SMN2 4651/4885TP53 734/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.