Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 1/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494742 | 0.91 | AKR1C3 (0.40) | AKR1C3AKR1C2NPC1MEN1MAPT | |
| SCHEMBL6479624 | 0.86 | BRPF1 (0.43) | AKR1C3AKR1C2TSHRBRPF1TUBB1 | |
| SCHEMBL6489065 | 0.84 | AKR1C3 (0.39) | AKR1C3AKR1C2BRPF1TUBB1HPGD | |
| SCHEMBL6490788 | 0.82 | TUBB1 (0.50) | AKR1C3AKR1C2BRPF1TUBB1NPC1 | |
| SCHEMBL6490326 | 0.80 | RORC (0.44) | AKR1C3AKR1C2CCR2HPGDALDH1A1 | |
| SCHEMBL6229626 | 0.78 | AKR1C3 (0.50) | AKR1C3AKR1C2BRPF1TUBB1CCR2 | |
| SCHEMBL6253573 | 0.78 | BRPF1 (0.41) | AKR1C3AKR1C2BRPF1TUBB1NPC1 | |
| SCHEMBL6480493 | 0.77 | CNR2 (0.43) | TSHRNPC1GLAHPGDCNR1 | |
| SCHEMBL6490426 | 0.77 | RORC (0.38) | AKR1C3AKR1C2TUBB1RORCCYP3A4 | |
| SCHEMBL6488118 | 0.77 | TYK2 (0.45) | AKR1C3AKR1C2NPC1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050215614-A1 | Substituted indoles and their use as hcv inhibitors | RIGEL PHARMACEUTICALS, INC. (US) | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215614-A1 | Substituted indoles and their use as hcv inhibitors | IDO1, IDO2, HAVCR2 | AKR1C3 1399/4885AKR1C2 1501/4885TSHR 3228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.