Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3998985 | 0.89 | CDC7 (0.46) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL2931108 | 0.84 | KDM4E (0.49) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL3041953 | 0.83 | KDM4E (0.49) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL4487254 | 0.81 | KDM4E (0.41) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL4000370 | 0.79 | CDC7 (0.51) | ALDH1A1KDM4EHPGDHSD17B10KDM5B | |
| SCHEMBL20304594 | 0.77 | KDM4E (0.38) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL3568709 | 0.77 | GSK3B (0.48) | ALDH1A1KDM4EPOLBRPS6KA2 | |
| SCHEMBL3325823 | 0.75 | KDM4E (0.47) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL3048039 | 0.74 | PARP1 (0.51) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL4485144 | 0.74 | ALDH1A1 (0.44) | ALDH1A1KDM4EPOLBHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050187223-A1 | Substituted heterocyclic compounds and methods of use | AMGEN, INC. | 2005-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050187223-A1 | Substituted heterocyclic compounds and methods of use | MYLK2, MUSK, MAPT | ALDH1A1 2475/4885KDM4E 3977/4885POLB 2525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.