Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 10/20 | 0.77 |
| ▸ | HTR2B | P41595 | 8/20 | 0.77 |
| ▸ | HTR2A | P28223 | 5/20 | 0.77 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.33 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494037 | 1.00 | HTR2C (0.77) | HTR2CHTR2BHTR2AEPHX2ROCK2 | |
| SCHEMBL6490562 | 1.00 | HTR2C (0.77) | HTR2CHTR2BHTR2AEPHX2ROCK2 | |
| SCHEMBL5408689 | 0.89 | HTR2C (0.90) | HTR2CHTR2BHTR2AEPHX2 | |
| SCHEMBL6783218 | 0.88 | HTR2C (0.59) | HTR2CHTR2BHTR2A | |
| SCHEMBL6501724 | 0.88 | HTR2C (0.59) | HTR2CHTR2BHTR2A | |
| SCHEMBL5426076 | 0.87 | HTR2C (1.00) | HTR2CHTR2BHTR2AEPHX2 | |
| SCHEMBL5636686 | 0.86 | HTR2C (0.72) | HTR2CHTR2BHTR2AEPHX2ROCK2 | |
| SCHEMBL5413099 | 0.86 | HTR2C (0.95) | HTR2CHTR2BHTR2AEPHX2 | |
| SCHEMBL6783531 | 0.86 | HTR2C (0.79) | HTR2CHTR2BHTR2AEPHX2ROCK2 | |
| SCHEMBL6790732 | 0.85 | HTR2C (0.57) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6849619-B2 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-02-01 | — | — | US | disclosed |
| US-20040186094-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-09-23 | — | — | US | disclosed |
| US-6699852-B2 | ANTISEROTONIN AGENTS; CENTRAL NERVOUS SYSTEM DISORDERS; ANTIDEPRESSANTS | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-03-02 | — | — | US | disclosed |
| US-20020173503-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2002-11-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020173503-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | HTR1A, HTR1B, HTR7 | HTR2C 11/4885HTR2B 5/4885HTR2A 21/4885 |
| US-20040186094-A1 | Substituted pyridoindoles as serotonin agonists and antagonists | HTR1A, HTR1B, HTR7 | HTR2C 11/4885HTR2B 5/4885HTR2A 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.