Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 3/20 | 0.50 |
| ▸ | JAK3 | P52333 | 3/20 | 0.50 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 1/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CCND1 | P24385 | 1/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.49 |
| ▸ | CCND3 | P30281 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27512507 | 0.82 | SMN1; SMN2 (0.56) | AURKAALDH1A1IKBKBL3MBTL1TNNI3K | |
| SCHEMBL1652316 | 0.81 | IKBKB (0.64) | AURKAAURKBGSK3BIKBKB | |
| SCHEMBL13440365 | 0.80 | AURKA (0.67) | AURKAAURKBCDK2GSK3AGSK3B | |
| SCHEMBL25667539 | 0.80 | ENPP2 (0.54) | JAK2JAK3PTK2GSK3BPIP4K2C | |
| Hydrochloric Acid SCHEMBL12813306 | 0.79 | SCN9A (0.57) | AURKAAURKBCDK2GSK3AGSK3B | |
| SCHEMBL3245767 | 0.76 | MEN1 (0.58) | GSK3BALDH1A1L3MBTL1 | |
| SCHEMBL18856685 | 0.76 | CDK1 (0.43) | AURKAAURKBJAK2JAK3PTK2 | |
| SCHEMBL3753567 | 0.76 | IKBKB (0.68) | JAK2JAK3GSK3BMAPK8IKBKB | |
| SCHEMBL30724687 | 0.75 | GPR39 (0.56) | AURKA | |
| SCHEMBL14264259 | 0.75 | CA1 (0.76) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4065157-A1 | CD19 AND CD22 CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF | Novartis AG (CH) | 2022-10-05 | — | — | EP | disclosed |
| US-6908920-B2 | Pyrimidine derivatives | ASTRAZENECA AB (SE) | 2005-06-21 | — | — | US | disclosed |