Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21826460 | 0.86 | LMNA (0.61) | NPC1RAB9ALMNAADORA3NR1H2 | |
| SCHEMBL6493882 | 0.84 | KDM4E (0.54) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL6494415 | 0.83 | NPC1 (0.42) | NPC1RAB9ANR1H4ADORA3NR1H2 | |
| SCHEMBL3166068 | 0.80 | NPC1 (0.58) | NPC1RAB9ALMNANR1H4ADORA3 | |
| SCHEMBL18015609 | 0.76 | KDM4E (0.40) | NPC1RAB9AADORA3KDM4EALDH1A1 | |
| SCHEMBL5480432 | 0.76 | KIF11 (0.45) | NPC1RAB9ALMNAKDM4EALDH1A1 | |
| SCHEMBL23624571 | 0.73 | NPC1 (0.60) | NPC1RAB9ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL24910446 | 0.73 | LMNA (0.33) | LMNAHSD17B10SMN1; SMN2KMT2AHRH4 | |
| SCHEMBL7375735 | 0.72 | LMNA (0.57) | NPC1RAB9ALMNANR1H4ADORA3 | |
| SCHEMBL13020884 | 0.72 | KMT2A (0.46) | LMNANR1H2NR1H3ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844347-B1 | Cyclic guanosine monophosphate modulators; cardiovascular diseases; guanylate cyclase activation | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-01-18 | — | — | US | disclosed |
| EP-1112266-B1 | SUBSTITUTED 4-AMINO-2-ARYL-PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | AVENTIS PHARMA GMBH (DE) | 2003-05-14 | — | — | EP | disclosed |
| EP-1112266-A1 | SUBSTITUTED 4-AMINO-2-ARYL-PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | Aventis Pharma Deutschland GmbH (DE) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000009496-A1 | SUBSTITUTED 4-AMINO-2-ARYL-PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-02-24 | — | — | WO | disclosed |