Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6488447 | 0.87 | GRIK1 (0.37) | GRIK1GRIA2ALDH1A1KDM4EKMT2A | |
| SCHEMBL6487605 | 0.83 | GRIK1 (0.45) | GRIK1ALDH1A1KDM4EKMT2AHPGD | |
| SCHEMBL6495295 | 0.80 | GRIK1 (0.39) | GRIK1GRIA2ALDH1A1KDM4EKMT2A | |
| SCHEMBL6493877 | 0.77 | GRIK1 (0.39) | GRIK1GRIA2L3MBTL1TSHR | |
| SCHEMBL6484834 | 0.77 | TACR1 (0.41) | ALDH1A1KDM4EKMT2AMEN1 | |
| SCHEMBL6484290 | 0.75 | GRIK1 (0.35) | GRIK1GRIA2KMT2AMEN1 | |
| SCHEMBL6493024 | 0.75 | GRIK1 (0.38) | GRIK1GRIA2KMT2AMEN1GAA | |
| SCHEMBL3391713 | 0.75 | GRIK1 (0.35) | GRIK1GRIA2ALDH1A1KDM4EKMT2A | |
| SCHEMBL6485218 | 0.74 | GRIK1 (0.61) | GRIK1GRIA2ALDH1A1KDM4EKMT2A | |
| SCHEMBL6500575 | 0.74 | GRIK1 (0.39) | GRIK1GRIA2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924294-B2 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 2005-08-02 | — | — | US | disclosed |
| US-20040053961-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY | 2004-03-18 | — | — | US | disclosed |
| EP-1351689-A2 | DERIVATIVES OF THE (3S, 4AR, 6S, 8AR) 6-PHENYLAMINO-1,2,3,4,4A,5,6,7,8,8A-DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AS EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS AND NEURODEGENERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2003024934-A2 | DERIVATIVES OF THE (3S, 4AR, 6S, 8AR) 6-PHENYLAMINO-1, 2, 3, 4, 4A, 5, 6, 7, 8, 8A-DECAHYDRO ISOQUINOLINE-3-CARBOXYLIC ACID AS EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS AND NEURODEGENERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053961-A1 | Excitatory amino acid receptor antagonists | SLC1A2, SLC1A1, SLC1A3 | GRIK1 12/4885GRIA2 24/4885ALDH1A1 1762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.