Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 2/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | FABP6 | P51161 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 3/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7171997 | 0.84 | CXCR4 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7165958 | 0.78 | AGTR2 (0.41) | AGTR2DPP4KMT2AMEN1CYP3A4 | |
| SCHEMBL6495295 | 0.77 | GRIK1 (0.39) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL6494432 | 0.77 | GRIK1 (0.44) | KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL7168130 | 0.76 | KMT2A (0.38) | KMT2AMEN1CYP3A4ALDH1A1 | |
| SCHEMBL7166169 | 0.75 | CXCR4 (0.43) | GRIN2BBCHEALDH1A1 | |
| SCHEMBL7170826 | 0.74 | CXCR4 (0.40) | GRIN2BKMT2AMEN1CYP3A4KDM4E | |
| SCHEMBL4388576 | 0.74 | AGTR2 (0.48) | AGTR2BCHEACHEKMT2ABACE1 | |
| SCHEMBL11048379 | 0.74 | AGTR2 (0.50) | AGTR2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL11048376 | 0.74 | AGTR2 (0.50) | AGTR2PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6924294-B2 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 2005-08-02 | — | — | US | disclosed |
| US-20040053961-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY | 2004-03-18 | — | — | US | disclosed |
| EP-1351689-A2 | DERIVATIVES OF THE (3S, 4AR, 6S, 8AR) 6-PHENYLAMINO-1,2,3,4,4A,5,6,7,8,8A-DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID AS EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS AND NEURODEGENERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2003024934-A2 | DERIVATIVES OF THE (3S, 4AR, 6S, 8AR) 6-PHENYLAMINO-1, 2, 3, 4, 4A, 5, 6, 7, 8, 8A-DECAHYDRO ISOQUINOLINE-3-CARBOXYLIC ACID AS EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROLOGICAL DISORDERS AND NEURODEGENERATIVE DISEASES | ELI LILLY AND COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053961-A1 | Excitatory amino acid receptor antagonists | SLC1A2, SLC1A1, SLC1A3 | TACR1 155/4885AGTR2 256/4885GRIN2B 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.