Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.64 |
| ▸ | RAB9A | P51151 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.63 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | APAF1 | O14727 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7157923 | 0.96 | ALDH1A1 (0.68) | NPC1RAB9AALDH1A1POLBCHRNA7 | |
| SCHEMBL7062009 | 0.87 | ALDH1A1 (0.57) | NPC1RAB9AALDH1A1POLBCHRNA7 | |
| SCHEMBL7219928 | 0.87 | ALDH1A1 (0.57) | NPC1RAB9AALDH1A1POLBCHRNA7 | |
| SCHEMBL6500280 | 0.83 | CHRNA7 (0.55) | ALDH1A1POLBCHRNA7 | |
| SCHEMBL7117739 | 0.82 | ALDH1A1 (0.64) | NPC1RAB9AALDH1A1POLBCHRNA7 | |
| SCHEMBL7127626 | 0.82 | ALDH1A1 (0.64) | NPC1RAB9AALDH1A1POLBCHRNA7 | |
| Hydrochloric Acid SCHEMBL7157621 | 0.82 | ALDH1A1 (0.63) | NPC1RAB9AALDH1A1POLBCHRNA7 | |
| Hydrochloric Acid SCHEMBL7198852 | 0.82 | ALDH1A1 (0.63) | NPC1RAB9AALDH1A1POLBCHRNA7 | |
| Hydrochloric Acid SCHEMBL7060978 | 0.82 | ALDH1A1 (0.63) | NPC1RAB9AALDH1A1POLBCHRNA7 | |
| SCHEMBL7063808 | 0.80 | NPC1 (0.62) | NPC1RAB9AALDH1A1POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919359-B2 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PFIZER INC (US) | 2005-07-19 | — | — | US | disclosed |
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207913-A1 | Azabicyclic-substituted-heteroaryl compounds for the treatment of disease | MALT1, WFS1, NR5A1 | NPC1 224/4885RAB9A 1437/4885ALDH1A1 625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.