SCHEMBL6494898

SCHEMBL6494898

[CH2]CCn1c(=O)[nH]c2ccccc21

nearest known ligand 0.66

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.64
HPGD P15428 2/20 0.64
HTT P42858 2/20 0.64
ALDH1A1 P00352 1/20 0.64
MAPT P10636 1/20 0.64
TSHR P16473 1/20 0.64
MAPK1 P28482 1/20 0.64
SMN1; SMN2 Q16637 1/20 0.64
TDP1 Q9NUW8 1/20 0.64
MEN1 O00255 1/20 0.64
CYP1A2 P05177 1/20 0.64
KMT2A Q03164 1/20 0.64
POLB P06746 1/20 0.59
HTR7 P34969 5/20 0.55
RAB9A P51151 1/20 0.55
P2RX7 Q99572 2/20 0.51
DAO P14920 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28297946 0.90 LMNA (0.69) LMNAHPGDHTTALDH1A1MAPT
SCHEMBL11049972 0.85 CYP1A2 (0.68) LMNAHPGDHTTALDH1A1MAPT
SCHEMBL30947438 0.85 LMNA (0.78) LMNAHPGDHTTALDH1A1MAPT
SCHEMBL961132 0.82 LMNA (0.64) LMNAHPGDHTTALDH1A1MAPT
SCHEMBL891366 0.82 LMNA (0.64) LMNAHPGDHTTALDH1A1MAPT
SCHEMBL2149052 0.82 LMNA (0.64) LMNAHPGDHTTALDH1A1MAPT
SCHEMBL30546561 0.82 LMNA (0.64) LMNAHPGDHTTALDH1A1MAPT
SCHEMBL763166 0.82 LMNA (0.64) LMNAHPGDHTTALDH1A1MAPT
SCHEMBL21729878 0.82 LMNA (0.64) LMNAHPGDHTTALDH1A1MAPT
SCHEMBL29695523 0.82 CYP1A2 (0.74) LMNAHPGDHTTALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3666757-A1 PROCESS FOR PREPARING A PIPERIDIN-4-ONE Karl-Franzens-Universität Graz (AT) 2020-06-17 EP claimed
EP-3666757-A1 PROCESS FOR PREPARING A PIPERIDIN-4-ONE Karl-Franzens-Universität Graz (AT) 2020-06-17 EP disclosed
US-6911442-B1 Quinoline derivatives as antibacterials SMITHKLINE BEECHAM P.L.C. (GB) 2005-06-28 US disclosed
EP-1187828-B1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2004-04-21 EP disclosed
EP-1187828-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM PLC (GB) 2002-03-20 EP disclosed
CN-1285828-A Imidazoylalkyl substituted with a five, six or seven membered heterocyclic ring containing one nitrogen atom SCHERING CORP (US) 2001-02-28 CN disclosed
WO-2000078748-A1 QUINOLINE DERIVATIVES AS ANTIBACTERIALS SMITHKLINE BEECHAM P.L.C. (GB) 2000-12-28 WO disclosed
EP-1028956-A1 IMIDAZOYLALKYL SUBSTITUTED WITH A FIVE, SIX OR SEVEN MEMBERED HETEROCYCLIC RING CONTAINING ONE NITROGEN ATOM SCHERING CORPORATION (US) 2000-08-23 EP disclosed
US-6100279-A HISTAMINE-H3 RECEPTOR ANTAGONIST; ANTIALLERGENIC AGENTS, ANTIASTHMATICS SCHERING CORPORATION (US) 2000-08-08 US disclosed
US-5932596-A NOVEL COMPOUNDS HAVING ANTAGONIST OR AGONIST ACTIVITY ON H3 RECEPTORS AND PHARMACEUTICAL COMPOSITIONS THEREOF; USE FOR TREATING DISORDERS INCLUDING ALLERGY, INFLAMMATION, HYPERTENSION, SLEEP DISORDERS, ALZHEIMER'S SCHERING CORPORATION (US) 1999-08-03 US disclosed
US-5463074-A Treating allergy, inflammation, hypertension, glaucoma, central nervous system disorders SCHERING CORPORATION (US) 1995-10-31 US disclosed
EP-0618905-B1 IMIDAZOLYL-ALKYL-PIPERAZINE AND -DIAZEPINE DERIVATIVES AS HISTAMINE H3 AGONISTS/ANTAGONISTS SCHERING CORP (US) 1995-10-04 EP disclosed
EP-0619818-A1 IMIDAZOYLALKYL SUBSTITUTED WITH A SIX MEMBERED NITROGEN CONTAINING HETEROCYCLIC RING. SCHERING CORP (US) 1994-10-19 EP disclosed
EP-0618905-A1 IMIDAZOLYL-ALKYL-PIPERAZINE AND -DIAZEPINE DERIVATIVES AS HISTAMINE H3 AGONISTS/ANTAGONISTS. SCHERING CORP (US) 1994-10-12 EP disclosed
WO-1993012093-A1 IMIDAZOLYL-ALKYL-PIPERAZINE AND -DIAZEPINE DERIVATIVES AS HISTAMINE H3 AGONISTS/ANTAGONISTS SCHERING CORPORATION (US) 1993-06-24 WO disclosed
WO-1993012108-A1 IMIDAZOLYL OR IMIDAZOYLALKYL SUBSTITUTED WITH A FOUR OR FIVE MEMBERED NITROGEN CONTAINING HETEROCYCLIC RING SCHERING CORPORATION (US) 1993-06-24 WO disclosed
WO-1993012107-A1 IMIDAZOYLALKYL SUBSTITUTED WITH A SIX MEMBERED NITROGEN CONTAINING HETEROCYCLIC RING SCHERING CORPORATION (US) 1993-06-24 WO disclosed
US-4388467-A NEUROLEPTIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1983-06-14 US disclosed
US-4334070-A NEUROLEPTIC AGENTS HOFFMANN-LA ROCHE INC. (US) 1982-06-08 US disclosed
EP-0035244-A2 Cycloalka(4,5)pyrrolo(2,3-g)isoquinolines, processes and intermediates for their preparation, and medicines containing them F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) 1981-09-09 EP disclosed