Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 6/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL318787 | 0.90 | LMNA (0.69) | LMNAHTTHPGDALDH1A1MAPT | |
| SCHEMBL30277537 | 0.90 | LMNA (0.69) | LMNAHTTHPGDALDH1A1MAPT | |
| SCHEMBL2149024 | 0.88 | LMNA (0.68) | LMNAHTTHPGDALDH1A1MAPT | |
| SCHEMBL8134198 | 0.87 | LMNA (0.66) | LMNAHTTHPGDALDH1A1MAPT | |
| SCHEMBL26189978 | 0.85 | MEN1 (0.68) | LMNAHTTHPGDALDH1A1MAPT | |
| SCHEMBL30947438 | 0.85 | LMNA (0.78) | LMNAHTTHPGDALDH1A1MAPT | |
| SCHEMBL21669395 | 0.84 | RAB9A (0.61) | LMNAHTTHPGDALDH1A1MAPT | |
| SCHEMBL763166 | 0.82 | LMNA (0.64) | LMNAHTTHPGDALDH1A1MAPT | |
| SCHEMBL21729878 | 0.82 | LMNA (0.64) | LMNAHTTHPGDALDH1A1MAPT | |
| SCHEMBL891366 | 0.82 | LMNA (0.64) | LMNAHTTHPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-8081464-A | — | — | None | — | — | JP | disclosed |
| US-20150368204-A1 | Sulfated Benzimidazolone Derivatives Having Mixed Serotonine Receptor Affinity | Salix Pharmaceuticals, Ltd | 2015-12-24 | — | — | US | disclosed |
| US-20150011564-A1 | Sulfated Benzimidazolone Derivatives Having Mixed Serotonine Receptor Affinity | SPROUT PHARMACEUTICALS, INC. (US) | 2015-01-08 | — | — | US | disclosed |
| US-8722682-B2 | Sulfated benzimidazolone derivatives having mixed serotonin receptor affinity | SPROUT PHARMACEUTICALS, INC. (US) | 2014-05-13 | — | — | US | disclosed |
| EP-2097389-B1 | SULFATED BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE RECEPTOR AFFINITY | BOEHRINGER INGELHEIM INT (DE) | 2011-09-14 | — | — | EP | disclosed |
| EP-1432420-B1 | BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS | ACADIA PHARM INC (US) | 2011-07-13 | — | — | EP | disclosed |
| US-20110015207-A1 | SULFATED BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE RECEPTOR AFFINITY | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-01-20 | — | — | US | disclosed |
| WO-2010146595-A2 | NOVEL POLYMORPHS OF FLIBANSERIN HYDROCHLORIDE | SYMED LABS LIMITED (IN) | 2010-12-23 | — | — | WO | disclosed |
| WO-2010128516-A2 | PROCESS FOR THE PREPARATION OF FLIBANSERIN INVOLVING NOVEL INTERMEDIATES | SYMED LABS LIMITED (IN) | 2010-11-11 | — | — | WO | disclosed |
| US-20100216840-A1 | BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS | ACADIA PHARMACEUTICALS INC. (US) | 2010-08-26 | — | — | US | disclosed |
| EP-0058975-A1 | Substituted N-(4-indolyl-piperidino-alkyl) benzimidazolones, processes for their preparation and their use as pharmaceutical preparations | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1982-09-01 | — | — | EP | disclosed |
| EP-0037713-A1 | Novel 1,3-dihydro-1-((1-piperidinyl)alkyl)-2H-benzimidazol-2-one derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-10-14 | — | — | EP | disclosed |
| US-4254127-A | ANTIEMETIC, NEUROLIPTIC AND ANTICONGESTIVE AGENT | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-03-03 | — | — | US | disclosed |
| US-4250176-A | BENZIMIDAZOLE-2-ONE, BENZOTHIAZOL-2-ONE, OR BENZOXAZOL-2-ONE SUBSTITUTIONS, ANTIANAPHALACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1981-02-10 | — | — | US | disclosed |
| US-4200641-A | ANTIANAPHYLACTIC AGENTS, ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1980-04-29 | — | — | US | disclosed |
| US-4044010-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-08-23 | — | — | US | disclosed |
| US-4035369-A | 1-Benzazolylalkyl-4-substituted-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1977-07-12 | — | — | US | disclosed |
| US-4006145-A | CNS DEPRESSANTS, NEUROLEPTICS | HOFFMANN-LA ROCHE INC. (US) | 1977-02-01 | — | — | US | disclosed |
| US-4006144-A | CNS DEPRESSANTS, NEUROLEPTICS | HOFFMANN-LA ROCHE INC. (US) | 1977-02-01 | — | — | US | disclosed |
| US-3954764-A | NEUROLEPTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1976-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011564-A1 | Sulfated Benzimidazolone Derivatives Having Mixed Serotonine Receptor Affinity | HTR3B, HTR3A, HTR1E | LMNA 4249/4885HTT 1316/4885HPGD 2234/4885 |
| US-20100216840-A1 | BENZIMIDAZOLIDINONE DERIVATIVES AS MUSCARINIC AGENTS | CHRM4, CHRM1, CHRM2 | LMNA 3610/4885HTT 2865/4885HPGD 2819/4885 |
| US-20150368204-A1 | Sulfated Benzimidazolone Derivatives Having Mixed Serotonine Receptor Affinity | HTR3B, HTR3A, HTR1E | LMNA 4258/4885HTT 1301/4885HPGD 2213/4885 |
| US-20110015207-A1 | SULFATED BENZIMIDAZOLONE DERIVATIVES HAVING MIXED SEROTONINE RECEPTOR AFFINITY | HTR3A, HTR3B, NPSR1 | LMNA 4318/4885HTT 1607/4885HPGD 1737/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.