Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1624 | 0.89 | AR (0.40) | TSHRLMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1463 | 0.83 | TSHR (0.47) | TSHRLMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL18597795 | 0.78 | LPAR1 (0.50) | TSHRRAB9ASMN1; SMN2L3MBTL1LPAR1 | |
| SCHEMBL2611 | 0.78 | LPAR1 (0.50) | TSHRRAB9ASMN1; SMN2L3MBTL1LPAR1 | |
| SCHEMBL1229 | 0.78 | LPAR1 (0.35) | TSHRLMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1804 | 0.78 | LPAR1 (0.35) | TSHRLMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1059 | 0.78 | LPAR1 (0.35) | TSHRLMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL7158 | 0.78 | TSHR (0.58) | TSHRRAB9ASMN1; SMN2L3MBTL1GAA | |
| SCHEMBL1932 | 0.78 | PKM (0.44) | TSHRLMNARAB9ASMN1; SMN2L3MBTL1 | |
| SCHEMBL6671 | 0.77 | MMP1 (0.39) | TSHRLMNARAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |