SCHEMBL6495190

SCHEMBL6495190

Cc1cc(-c2noc(-c3ccc(Cl)cc3)n2)ccc1/N=C/N(C)C

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 1/20 0.52
NPC1 O15118 9/20 0.48
RAB9A P51151 8/20 0.48
SMN1; SMN2 Q16637 5/20 0.48
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C19 P33261 1/20 0.48
MAPT P10636 3/20 0.44
ALDH1A1 P00352 2/20 0.43
TP53 P04637 2/20 0.43
CASP3 P42574 3/20 0.41
SENP8 Q96LD8 1/20 0.41
SENP7 Q9BQF6 1/20 0.41
SENP6 Q9GZR1 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
S1PR1 P21453 4/20 0.41
TSHR P16473 2/20 0.41
KDM4E B2RXH2 1/20 0.41
POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6495191 1.00 NR1H4 (0.52) NR1H4NPC1RAB9ASMN1; SMN2MEN1
SCHEMBL6495198 0.91 NR1H4 (0.52) NR1H4NPC1RAB9ASMN1; SMN2MEN1
Chlordimeform SCHEMBL29356157 0.74 CYP3A4 (0.53) NPC1RAB9ASMN1; SMN2MEN1KMT2A
Chlordimeform SCHEMBL5510656 0.74 CYP3A4 (0.53) NPC1RAB9ASMN1; SMN2MEN1KMT2A
Chlordimeform SCHEMBL22934 0.74 CYP3A4 (0.53) NPC1RAB9ASMN1; SMN2MEN1KMT2A
Chlordimeform SCHEMBL74460 0.74 CYP3A4 (0.53) NPC1RAB9ASMN1; SMN2MEN1KMT2A
Chlordimeform SCHEMBL8380830 0.74 CYP3A4 (0.53) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL6495701 0.74 NR1H4 (0.63) NR1H4NPC1RAB9ASMN1; SMN2MEN1
Chlordimeform SCHEMBL160021 0.73 CYP3A4 (0.51) NPC1RAB9ASMN1; SMN2MEN1KMT2A
Chlordimeform SCHEMBL160020 0.73 CYP3A4 (0.51) NPC1RAB9ASMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6893650-B1 N2-phenylamidine derivatives BAYER CROPSCIENCE GMBH (DE) 2005-05-17 US disclosed
EP-1150944-B1 N2-PHENYLAMIDINE DERIVATIVES BAYER CROPSCIENCE GMBH (DE) 2003-08-20 EP disclosed
EP-1150944-A1 N2-PHENYLAMIDINE DERIVATIVES Aventis CropScience GmbH (DE) 2001-11-07 EP disclosed
WO-2000046184-A1 N2-PHENYLAMIDINE DERIVATIVES AVENTIS CROPSCIENCE GMBH (FR) 2000-08-10 WO disclosed