Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.50 |
| ▸ | NPY2R | P49146 | 1/20 | 0.50 |
| ▸ | PDE3B | Q13370 | 13/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6503803 | 0.85 | SMN1; SMN2 (0.67) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL10353452 | 0.84 | SMN1; SMN2 (0.81) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL2846257 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL8302890 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL927560 | 0.78 | SMN1; SMN2 (0.70) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL9687996 | 0.78 | SMN1; SMN2 (0.70) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL8481664 | 0.77 | LMNA (0.56) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL10556720 | 0.76 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL6331085 | 0.76 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R | |
| SCHEMBL7273533 | 0.76 | SMN1; SMN2 (0.68) | SMN1; SMN2KCNH2LMNAMAPTNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972288-B1 | 4-amino-quinazoline and quinoline derivatives having an inhibitory effect on signal transduction mediated by tyrosine kinases | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2005-12-06 | — | — | US | disclosed |
| US-6867206-B1 | 6-carboxyphenyldihydropyridazinone derivatives and use thereof | BAYER AKTIENGESELLSCHAFT (DE) | 2005-03-15 | — | — | US | disclosed |
| EP-1196392-A1 | 6-CARBOXYPHENYLDIHYDROPYRIDAZINONE DERIVATIVES AND USE THEREOF | Bayer Aktiengesellschaft (DE) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001000589-A1 | 6-CARBOXYPHENYLDIHYDROPYRIDAZINONE DERIVATIVES AND USE THEREOF | BAYER AKTIENGESELLSCHAFT (DE) | 2001-01-04 | — | — | WO | disclosed |