Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 4/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499247 | 0.82 | MAPK1 (0.35) | DPP4CYP2D6 | |
| SCHEMBL13091292 | 0.79 | HTR1D (0.42) | DPP4CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL20256735 | 0.77 | DPP4 (0.38) | DPP4CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL2867341 | 0.72 | PARP1 (0.37) | DPP4CYP2D6IDO1PARP1 | |
| SCHEMBL6097165 | 0.72 | ALDH1A1 (0.45) | AOC3CYP3A4 | |
| SCHEMBL3536393 | 0.72 | TAAR1 (0.55) | PTGDRTAAR1IDO1 | |
| SCHEMBL27911941 | 0.71 | DPP4 (0.41) | DPP4CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL27911944 | 0.71 | DPP4 (0.41) | DPP4CYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL20256892 | 0.69 | MAOB (0.40) | PTGDRPARP1 | |
| SCHEMBL583371 | 0.69 | TAAR1 (0.52) | CYP3A4SLC6A2SLC6A4SLC6A3LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |