Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 5/20 | 0.36 |
| ▸ | KMO | O15229 | 5/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4697712 | 0.77 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL14742168 | 0.71 | CSNK2A1 (0.47) | CSNK2A1HPGDPDE4AKMOPDE4B | |
| SCHEMBL6506569 | 0.71 | RIPK1 (0.38) | HPGDPDE4AKMOPDE4BPDE4C | |
| SCHEMBL20836421 | 0.70 | SLC6A4 (0.38) | CSNK2A1MCHR1SLC6A4 | |
| SCHEMBL25333614 | 0.69 | CSNK2A1 (0.38) | CSNK2A1HPGDSLC6A4 | |
| SCHEMBL2350414 | 0.69 | CA12 (0.35) | — | |
| SCHEMBL2887724 | 0.68 | CSNK2A1 (0.37) | CSNK2A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3545939 | 0.68 | ALDH1A1 (0.33) | — | |
| SCHEMBL28806755 | 0.68 | MCHR1 (0.36) | CSNK2A1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2104303 | 0.68 | CSNK2A1 (0.44) | CSNK2A1HPGDPDE4AKMOPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |