Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 5/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.47 |
| ▸ | FNTA | P49354 | 2/20 | 0.44 |
| ▸ | FNTB | P49356 | 2/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL654606 | 1.00 | CHRNB2 (0.47) | CHRNB2CHRNA4CHRNB4CHRNA3FNTA | |
| SCHEMBL650793 | 0.85 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2 | |
| SCHEMBL653614 | 0.85 | CHRNB2 (0.44) | CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2 | |
| SCHEMBL652628 | 0.84 | CHRNB2 (0.48) | CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2 | |
| SCHEMBL929833 | 0.82 | CHRNB2 (0.49) | CHRNB2CHRNA4CHRNB4CHRNA3FNTA | |
| SCHEMBL651870 | 0.82 | GRIN2B (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2 | |
| SCHEMBL651154 | 0.82 | GRIN2B (0.50) | CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2 | |
| SCHEMBL3582114 | 0.81 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3583494 | 0.81 | CHRNB2 (0.58) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL653364 | 0.79 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119635-B2 | Diazabicyclic central nervous system active agents | ABBOTT LABORATORIES (US) | 2012-02-21 | — | — | US | disclosed |
| EP-2316836-A1 | Substituted diazabicycloalkane derivatives as ligands at alpha 7 nicotinic acetylcholine receptors | Abbott Laboratories (US) | 2011-05-04 | — | — | EP | disclosed |
| EP-2298775-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2295437-A1 | Diazabicyclic central nervous system active agents | Abbott Laboratories (US) | 2011-03-16 | — | — | EP | disclosed |
| US-7872010-B2 | Substituted diazabicycloalkane derivatives having affinity for nicotinic acetylcholine receptors | ABBOTT LABORATORIES (US) | 2011-01-18 | — | — | US | disclosed |