SCHEMBL653614

SCHEMBL653614

O=C(OCc1ccccc1)N1C[C@@H]2CN(c3cncc(Br)c3)[C@@H]2C1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.44
CHRNA4 P43681 2/20 0.44
CHRNB4 P30926 1/20 0.44
CHRNA3 P32297 1/20 0.44
KCNK3 O14649 1/20 0.43
KCNK9 Q9NPC2 1/20 0.43
SMN1; SMN2 Q16637 3/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
CYP2C19 P33261 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
F13A1 P00488 1/20 0.39
TGM2 P21980 1/20 0.39
TGM1 P22735 1/20 0.39
GRIN2B Q13224 5/20 0.39
CYP2D6 P10635 4/20 0.39
CYP2C9 P11712 4/20 0.39
CYP3A4 P08684 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL650793 1.00 CHRNB2 (0.44) CHRNB2CHRNA4CHRNB4CHRNA3KCNK3
SCHEMBL652628 0.87 CHRNB2 (0.48) CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2
SCHEMBL649574 0.85 CHRNB2 (0.47) CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2
SCHEMBL654606 0.85 CHRNB2 (0.47) CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2
SCHEMBL651870 0.84 GRIN2B (0.50) CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2
SCHEMBL651154 0.84 GRIN2B (0.50) CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2
SCHEMBL653674 0.82 CHRNB2 (0.50) CHRNB2CHRNA4CHRNB4CHRNA3HCRTR1
SCHEMBL929833 0.81 CHRNB2 (0.49) CHRNB2CHRNA4CHRNB4CHRNA3KCNK3
SCHEMBL654459 0.81 CHRNB2 (0.45) CHRNB2CHRNA4CHRNB4CHRNA3SMN1; SMN2
SCHEMBL3579727 0.80 CHRNB2 (0.56) CHRNB2CHRNA4CHRNB4CHRNA3HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8119635-B2 Diazabicyclic central nervous system active agents ABBOTT LABORATORIES (US) 2012-02-21 US disclosed
EP-2298775-A1 Diazabicyclic central nervous system active agents Abbott Laboratories (US) 2011-03-23 EP disclosed
EP-2295437-A1 Diazabicyclic central nervous system active agents Abbott Laboratories (US) 2011-03-16 EP disclosed