Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378255 | 0.84 | MKNK1 (0.51) | MKNK1MKNK2MAP4K4MYCERN1 | |
| SCHEMBL6506138 | 0.81 | MEN1 (0.39) | NPC1RAB9A | |
| SCHEMBL13381599 | 0.80 | MKNK1 (0.45) | MKNK1MKNK2MAP4K4MYCERN1 | |
| SCHEMBL6497749 | 0.80 | NPC1 (0.42) | NPC1RAB9A | |
| SCHEMBL19718861 | 0.79 | MEN1 (0.44) | — | |
| SCHEMBL14063572 | 0.74 | MKNK1 (0.62) | MKNK1MKNK2MAP4K4MYCERN1 | |
| SCHEMBL4808706 | 0.71 | CNR1 (0.38) | — | |
| SCHEMBL7375985 | 0.68 | MKNK1 (0.53) | MKNK1MKNK2MAP4K4CHEK2NPC1 | |
| SCHEMBL10026546 | 0.68 | CA1 (0.59) | MKNK1MKNK2PARP10MAP4K4ERN1 | |
| SCHEMBL7380578 | 0.68 | MAP4K4 (0.48) | MKNK1MKNK2MAP4K4MYCERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844347-B1 | Cyclic guanosine monophosphate modulators; cardiovascular diseases; guanylate cyclase activation | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-01-18 | — | — | US | disclosed |
| EP-1112266-B1 | SUBSTITUTED 4-AMINO-2-ARYL-PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | AVENTIS PHARMA GMBH (DE) | 2003-05-14 | — | — | EP | disclosed |
| EP-1112266-A1 | SUBSTITUTED 4-AMINO-2-ARYL-PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | Aventis Pharma Deutschland GmbH (DE) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000009496-A1 | SUBSTITUTED 4-AMINO-2-ARYL-PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-02-24 | — | — | WO | disclosed |