Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.51 |
| ▸ | MYC | P01106 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13381599 | 0.88 | MKNK1 (0.45) | MKNK1MKNK2MYCMAP4K4ERN1 | |
| SCHEMBL6495791 | 0.84 | MKNK1 (0.42) | MKNK1MKNK2MYCMAP4K4ERN1 | |
| SCHEMBL7375985 | 0.78 | MKNK1 (0.53) | MKNK1MKNK2MAP4K4CHEK2IKBKB | |
| SCHEMBL7380578 | 0.78 | MAP4K4 (0.48) | MKNK1MKNK2MYCMAP4K4ERN1 | |
| SCHEMBL11586178 | 0.77 | ALDH1A1 (0.53) | NPC1RAB9ACA14 | |
| SCHEMBL15748062 | 0.76 | MKNK1 (0.53) | MKNK1MKNK2MAP4K4IKBKBNPC1 | |
| SCHEMBL2117350 | 0.76 | CYP3A4 (0.54) | ERN1 | |
| SCHEMBL1002578 | 0.75 | CA2 (0.67) | MKNK1MKNK2MAP4K4ERN1CA12 | |
| SCHEMBL4883417 | 0.74 | MKNK1 (0.59) | MKNK1MKNK2MAP4K4ERN1CHEK2 | |
| SCHEMBL9506862 | 0.73 | LCK (0.45) | MKNK1MKNK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372751-B1 | DRUGS WITH BENZENE AND PYRIMIDINE RINGS | BERLEX LABORATORIES, INC. | 2002-04-16 | — | — | US | disclosed |
| EP-1135131-A4 | ARYL AND HETEROCYCLYL SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTI-COAGULANTS | BERLEX LAB (US) | 2002-01-02 | — | — | EP | disclosed |
| EP-1135131-A1 | ARYL AND HETEROCYCLYL SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTI-COAGULANTS | BERLEX LABORATORIES, INC. (US) | 2001-09-26 | — | — | EP | disclosed |
| US-6127376-A | A BLOOD FACTOR XA ENZYME INHIBITOR TREATING A HUMAN HAVING A DISEASE-STATE CHARACTERIZED BY THROMBOTIC ACTIVITY | BERLEX LABORATORIES, INC. (US) | 2000-10-03 | — | — | US | disclosed |
| WO-2000033844-A1 | ARYL AND HETEROCYCLYL SUBSTITUTED PYRIMIDINE DERIVATIVES AS ANTI-COAGULANTS | BERLEX LATORATORIES, INC. (US) | 2000-06-15 | — | — | WO | disclosed |