Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4808706 | 0.85 | CNR1 (0.38) | TSHRCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL6506138 | 0.85 | MEN1 (0.39) | NPC1RAB9AMAPTKMT2AALDH1A1 | |
| SCHEMBL19718861 | 0.83 | MEN1 (0.44) | MAPTTP53KMT2AADORA3MEN1 | |
| SCHEMBL6495195 | 0.83 | NPC1 (0.44) | NPC1RAB9AMAPTTP53KMT2A | |
| SCHEMBL3161969 | 0.82 | NPC1 (0.54) | NPC1RAB9AMAPTTP53KMT2A | |
| SCHEMBL6495791 | 0.80 | MKNK1 (0.42) | NPC1RAB9A | |
| SCHEMBL6494415 | 0.73 | NPC1 (0.42) | NPC1RAB9AMAPTKMT2AALDH1A1 | |
| SCHEMBL2609386 | 0.72 | MAPT (0.51) | NPC1RAB9AMAPTTP53KMT2A | |
| SCHEMBL28827842 | 0.72 | NPC1 (0.52) | NPC1RAB9AMAPTTP53KMT2A | |
| SCHEMBL6494121 | 0.71 | ALDH1A1 (0.51) | NPC1RAB9AMAPTTP53KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6844347-B1 | Cyclic guanosine monophosphate modulators; cardiovascular diseases; guanylate cyclase activation | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-01-18 | — | — | US | disclosed |
| EP-1112266-B1 | SUBSTITUTED 4-AMINO-2-ARYL-PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | AVENTIS PHARMA GMBH (DE) | 2003-05-14 | — | — | EP | disclosed |
| EP-1112266-A1 | SUBSTITUTED 4-AMINO-2-ARYL-PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | Aventis Pharma Deutschland GmbH (DE) | 2001-07-04 | — | — | EP | disclosed |
| WO-2000009496-A1 | SUBSTITUTED 4-AMINO-2-ARYL-PYRIMIDINES, THEIR PRODUCTION AND USE AND PHARMACEUTICAL PREPARATIONS CONTAINING SAME | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-02-24 | — | — | WO | disclosed |