Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 3/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | SMO | Q99835 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780518 | 1.00 | CRHR1 (0.40) | CRHR1ABL1CYP3A4CYP2C9PIK3CA | |
| SCHEMBL5780516 | 1.00 | CRHR1 (0.40) | CRHR1ABL1CYP3A4CYP2C9PIK3CA | |
| SCHEMBL6508023 | 0.91 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5785022 | 0.91 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL5785025 | 0.91 | CRHR1 (0.46) | CRHR1 | |
| SCHEMBL6496447 | 0.90 | CRHR1 (0.42) | CRHR1ABL1PIK3CA | |
| SCHEMBL5787587 | 0.90 | CRHR1 (0.42) | CRHR1ABL1PIK3CA | |
| SCHEMBL5787588 | 0.90 | CRHR1 (0.42) | CRHR1ABL1PIK3CA | |
| SCHEMBL6498701 | 0.88 | CRHR1 (0.42) | CRHR1 | |
| SCHEMBL7244912 | 0.86 | CRHR1 (0.41) | CRHR1ABL1CYP3A4CYP2C9PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050020601-A1 | Novel pyrazinones as CRF1 receptor antagonists | PFIZER INC | 2005-01-27 | — | — | US | claimed |
| US-20050020601-A1 | Novel pyrazinones as CRF1 receptor antagonists | PFIZER INC | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020601-A1 | Novel pyrazinones as CRF1 receptor antagonists | CRHR1, CRHR2, CRH | CRHR1 1/4885ABL1 4315/4885CYP3A4 1513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.