Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.82 |
| ▸ | MAPT | P10636 | 3/20 | 0.82 |
| ▸ | PDE4A | P27815 | 2/20 | 0.82 |
| ▸ | SNCA | P37840 | 2/20 | 0.82 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.82 |
| ▸ | PGR | P06401 | 1/20 | 0.82 |
| ▸ | HTR1A | P08908 | 1/20 | 0.82 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.82 |
| ▸ | DRD3 | P35462 | 1/20 | 0.82 |
| ▸ | DHODH | Q02127 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974934 | 0.91 | MAPT (0.74) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menaquinone-2 SCHEMBL30606255 | 0.91 | PTGS1 (0.97) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menaquinone-2 SCHEMBL29355593 | 0.91 | PTGS1 (0.97) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menaquinone-2 SCHEMBL416517 | 0.91 | PTGS1 (0.97) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menaquinone-2 SCHEMBL571905 | 0.91 | PTGS1 (0.97) | PTGS1MAPTPDE4ASNCAPDE3A | |
| SCHEMBL974935 | 0.91 | MAPT (0.74) | PTGS1MAPTPDE4ASNCAPDE3A | |
| SCHEMBL10055449 | 0.90 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A | |
| SCHEMBL571907 | 0.90 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menatetrenone SCHEMBL571912 | 0.90 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menaquinone 6 SCHEMBL244452 | 0.90 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050176778-A1 | Isoprenyl derivatives and their use in the title treatment and prevention of osteoporosis and cardiovascular calcification | VITAK BV (NL) | 2005-08-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176778-A1 | Isoprenyl derivatives and their use in the title treatment and prevention of osteoporosis and cardiovascular calcification | SOST, PTH1R, PTMS | PTGS1 789/4885MAPT 4841/4885PDE4A 2826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.