Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 4/20 | 0.97 |
| ▸ | MAPT | P10636 | 3/20 | 0.97 |
| ▸ | PDE4A | P27815 | 2/20 | 0.97 |
| ▸ | SNCA | P37840 | 2/20 | 0.97 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.97 |
| ▸ | PGR | P06401 | 1/20 | 0.97 |
| ▸ | HTR1A | P08908 | 1/20 | 0.97 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.97 |
| ▸ | DRD3 | P35462 | 1/20 | 0.97 |
| ▸ | MAOB | P27338 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | DHODH | Q02127 | 2/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menaquinone-2 SCHEMBL29355593 | 1.00 | PTGS1 (0.97) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menaquinone-2 SCHEMBL30606255 | 1.00 | PTGS1 (0.97) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menaquinone-2 SCHEMBL416517 | 1.00 | PTGS1 (0.97) | PTGS1MAPTPDE4ASNCAPDE3A | |
| SCHEMBL571907 | 0.99 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menatetrenone SCHEMBL571912 | 0.99 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A | |
| SCHEMBL8709976 | 0.99 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menaquinone 7 SCHEMBL436068 | 0.99 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menaquinone 6 SCHEMBL244452 | 0.99 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A | |
| SCHEMBL14164356 | 0.99 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A | |
| Menatetrenone SCHEMBL8703544 | 0.99 | PTGS1 (1.00) | PTGS1MAPTPDE4ASNCAPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140031432-A1 | TREATMENT OF MITOCHONDRIAL DISEASES WITH VITAMIN K | AMPERE LIFE SCIENCES, INC. (US) | 2014-01-30 | — | — | US | disclosed |
| EP-2601168-A1 | TREATMENT OF MITOCHONDRIAL DISEASES WITH VITAMIN K | Ampere Life Sciences, Inc. (US) | 2013-06-12 | — | — | EP | disclosed |
| WO-2012170773-A1 | ADJUNCTIVE THERAPY FOR THE TREATMENT OF MITOCHONDRIAL DISORDERS WITH QUINONES AND NAPHTHOQUINONES | EDISON PHARMACEUTICALS, INC. (US) | 2012-12-13 | — | — | WO | disclosed |
| WO-2012019032-A1 | TREATMENT OF MITOCHONDRIAL DISEASES WITH VITAMIN K | AMPERE LIFE SCIENCES, INC. (US) | 2012-02-09 | — | — | WO | disclosed |
| EP-0872903-B1 | Method for making hydrogen storage alloy powder and electrode comprising the alloy powder | SHINETSU CHEMICAL CO (JP) | 2001-10-04 | — | — | EP | disclosed |
| US-6277519-B1 | QUENCHING AN ALLOY MELT; COMMINUTION | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2001-08-21 | — | — | US | disclosed |
| US-6096144-A | TREATING WITH ACIDIC OR ALKALINE SOLUTION OF CONJUGATED UNSATURATED COMPOUND WITH AT LEAST 5 BONDS | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2000-08-01 | — | — | US | disclosed |
| US-5858571-A | TREATING A PULVERIZED HYDROGEN ABSORBING ALLOY WITH A SOLUTION COMPRISING A CONJUGATED UNSATURATED COMPOUND | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1999-01-12 | — | — | US | disclosed |
| EP-0872903-A1 | Method for making hydrogen storage alloy powder and electrode comprising the alloy powder | Shin-Etsu Chemical Co., Ltd. (JP) | 1998-10-21 | — | — | EP | disclosed |
| EP-0613877-B1 | Preparation process of quinone derivative and intermediate for the preparation thereof | EISAI KAGAKU KK (JP) | 1998-05-20 | — | — | EP | disclosed |
| US-5608092-A | INTERMEDIATES FOR VITAMIN K DERIVATIVES | EISAI CHEMICAL CO., LTD. (JP) | 1997-03-04 | — | — | US | disclosed |
| US-5476955-A | Process for the preparation of a quinone derivative | EISAI CHEMICAL CO., LTD. (JP) | 1995-12-19 | — | — | US | disclosed |
| US-5412124-A | Preparation process of naphthoquinone derivative and intermediate for the preparation thereof | EISAI CHEMICAL CO., LTD. (JP) | 1995-05-02 | — | — | US | disclosed |
| EP-0636598-A1 | Preparation process of naphthoquinone derivatives and intermediates for the preparation thereof | EISAI CHEMICAL CO., LTD. (JP) | 1995-02-01 | — | — | EP | disclosed |
| EP-0613877-A1 | Preparation process of quinone derivative and intermediate for the preparation thereof | EISAI CHEMICAL CO., LTD. (JP) | 1994-09-07 | — | — | EP | disclosed |
| EP-0172427-B1 | PROCESS FOR PRODUCTION OF VINYL CHLORIDE POLYMER | Shin-Etsu Chemical Co., Ltd. (JP) | 1989-07-05 | — | — | EP | disclosed |
| US-4818441-A | MEMBRANE STABILIZERS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1989-04-04 | — | — | US | disclosed |
| US-4758639-A | Process for production of vinyl polymer | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1988-07-19 | — | — | US | disclosed |
| US-4757124-A | Suspension or emulsion polymerizing vinyl chloride monomer or mixture of vinyl chloride with vinyl monomer copolymerizable therewith in reactor with walls coated with antiscaling compound containing dye or pigments | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1988-07-12 | — | — | US | disclosed |
| EP-0172427-A2 | Process for production of vinyl chloride polymer | Shin-Etsu Chemical Co., Ltd. (JP) | 1986-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031432-A1 | TREATMENT OF MITOCHONDRIAL DISEASES WITH VITAMIN K | FH, COQ8A, BCKDK | PTGS1 2269/4885MAPT 1790/4885PDE4A 2847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.