Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.51 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.50 |
| ▸ | FEN1 | P39748 | 2/20 | 0.50 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.42 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL352099 | 0.86 | KDM4E (0.55) | KDM4EALDH1A1GAAERCC1FEN1 | |
| SCHEMBL6505829 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1GAAERCC1FEN1 | |
| SCHEMBL6506142 | 0.79 | DAO (0.44) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL3418775 | 0.78 | KDM4E (1.00) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL9629249 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL3995172 | 0.77 | RARA (0.60) | KDM4EALDH1A1GAANPC1SMN1; SMN2 | |
| SCHEMBL10091957 | 0.76 | KDM4E (0.61) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL6498884 | 0.75 | DAO (0.44) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL6505414 | 0.73 | HPGD (0.47) | KDM4EALDH1A1GAARAB9ANPC1 | |
| SCHEMBL10717905 | 0.73 | RARA (0.52) | KDM4EALDH1A1GAARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1228327-C | Carboxylic acid derivatives and drugs containing the same | EISAI CO LTD (JP) | 2005-11-23 | — | — | CN | disclosed |
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| CN-1377336-A | Carboxylic acid derivatives and drugs containing the same | EISAI CO LTD (JP) | 2002-10-30 | — | — | CN | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |