Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10091957 | 0.81 | KDM4E (0.61) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL6496780 | 0.77 | KDM4E (0.64) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL20836643 | 0.77 | KDM4E (0.60) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL6760831 | 0.76 | KDM4E (0.49) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL352099 | 0.76 | KDM4E (0.55) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL10717905 | 0.75 | RARA (0.52) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL17374796 | 0.73 | KDM4E (0.56) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL2375004 | 0.72 | KDM4E (0.58) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL17374827 | 0.72 | TRPM8 (0.58) | KDM4EALDH1A1GAANPC1RAB9A | |
| SCHEMBL9630548 | 0.72 | ALOX5 (0.62) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124342-A | Antiinflammatory, antiarthritic agents; antiallergens; skin disorders | ABBOTT LABORATORIES (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0457803-A4 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | — | 1991-12-04 | — | — | EP | disclosed |
| EP-0457803-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009801-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |
| WO-1990009381-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-08-23 | — | — | WO | disclosed |