Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ERCC1 | P07992 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | ERCC4 | Q92889 | 2/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.35 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | XBP1 | P17861 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496871 | 0.84 | KMT2A (0.42) | KMT2AMEN1SMN1; SMN2ERCC1FEN1 | |
| SCHEMBL6496874 | 0.80 | ERCC1 (0.41) | KMT2AMEN1SMN1; SMN2ERCC1FEN1 | |
| SCHEMBL288730 | 0.74 | ALDH1A1 (0.32) | ALDH1A1TSHR | |
| SCHEMBL6427039 | 0.73 | ERCC1 (0.47) | KMT2AMEN1ERCC1FEN1ERCC4 | |
| SCHEMBL1410 | 0.72 | ERCC1 (0.62) | KMT2AMEN1ERCC1FEN1ERCC4 | |
| SCHEMBL710689 | 0.72 | ERCC1 (0.62) | KMT2AMEN1ERCC1FEN1ERCC4 | |
| SCHEMBL29361703 | 0.72 | ERCC1 (0.62) | KMT2AMEN1ERCC1FEN1ERCC4 | |
| Acetic Acid SCHEMBL2369439 | 0.70 | ERCC1 (0.52) | KMT2AMEN1ERCC1FEN1ERCC4 | |
| SCHEMBL2824836 | 0.70 | ERCC1 (0.60) | KMT2AMEN1ERCC1FEN1ERCC4 | |
| SCHEMBL2824834 | 0.70 | ERCC1 (0.60) | KMT2AMEN1ERCC1FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884874-B2 | Process and intermediates | SMITHKLINE BEECHAM CORPORATION (US) | 2005-04-26 | — | — | US | disclosed |
| US-20040014980-A1 | Such as n-methyl-alanine derivatives; for preparing antibody/maytansinoid complexes | SMITHKLINE BEECHAM PLC | 2004-01-22 | — | — | US | disclosed |
| US-6570024-B2 | N-methyl-L-alanine derivatives derivatives used for preparing cell binding agent/maytansinoid complexes | SMITHKLINE BEECHAM CORPORATION | 2003-05-27 | — | — | US | disclosed |
| US-20020156318-A1 | Process and intermediates | GLAXOSMITHKLINE LLC | 2002-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014980-A1 | Such as n-methyl-alanine derivatives; for preparing antibody/maytansinoid complexes | HGFAC, ANPEP, AAAS | KMT2A 1018/4885MEN1 386/4885SMN1; SMN2 1417/4885 |
| US-20020156318-A1 | Process and intermediates | HGFAC, MTAP, SPR | KMT2A 3698/4885MEN1 869/4885SMN1; SMN2 936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.