Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.65 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.60 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.60 |
| ▸ | CA12 | O43570 | 2/20 | 0.60 |
| ▸ | CA4 | P22748 | 2/20 | 0.60 |
| ▸ | CA6 | P23280 | 2/20 | 0.60 |
| ▸ | CA5A | P35218 | 2/20 | 0.60 |
| ▸ | CA7 | P43166 | 2/20 | 0.60 |
| ▸ | CA9 | Q16790 | 2/20 | 0.60 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.60 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6497449 | 1.00 | KMT2A (0.65) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL3089734 | 0.91 | KMT2A (0.73) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL3089736 | 0.91 | KMT2A (0.73) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL7312618 | 0.85 | THRB (0.66) | KMT2ALMNAALDH1A1MAPTHDAC3 | |
| SCHEMBL7312615 | 0.85 | THRB (0.66) | KMT2ALMNAALDH1A1MAPTHDAC3 | |
| SCHEMBL22071063 | 0.84 | LMNA (0.84) | LMNAAKR1B10AKR1B1CA12CA4 | |
| SCHEMBL312287 | 0.83 | KMT2A (0.92) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL380997 | 0.83 | KMT2A (0.71) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| SCHEMBL25770022 | 0.82 | MAPT (0.56) | KMT2ASLC6A2SLC6A3TDP1LMNA | |
| Benzyl Cinnamate SCHEMBL30513717 | 0.81 | LMNA (0.90) | LMNAAKR1B10AKR1B1CA12CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900318-B1 | 1,4,5,6-tetrahydropyrimidine derivative as a vitronectin inhibitor | AVENTIS PHARMA DEUTSCLAND GMBH (DE) | 2005-05-31 | — | — | US | disclosed |
| EP-1204646-B1 | 1,4,5,6 -TETRAHYDROPYRIMIDINE DERIVATIVE AS A VITRONECTIN INHIBITOR | AVENTIS PHARMA GMBH (DE) | 2004-12-29 | — | — | EP | disclosed |
| EP-1204646-A1 | 1,4,5,6 -TETRAHYDROPYRIMIDINE DERIVATIVE AS A VITRONECTIN INHIBITOR | Aventis Pharma Deutschland GmbH (DE) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001007417-A1 | 1,4,5,6-TETRAHYDROPYRIMIDINE DERIVATIVE AS A VITRONECTIN INHIBITOR | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-02-01 | — | — | WO | disclosed |
| EP-1070707-A1 | 1,4,5,6-tetrahydropyrimidine derivative as a vitronectin inhibitor | Aventis Pharma Deutschland GmbH (DE) | 2001-01-24 | — | — | EP | disclosed |