Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.62 |
| ▸ | AR | P10275 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | PGR | P06401 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.62 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL960384 | 0.84 | LMNA (0.61) | LMNAARSMN1; SMN2CYP3A4NPSR1 | |
| SCHEMBL11623150 | 0.81 | LMNA (0.58) | LMNAARSMN1; SMN2CYP3A4NPSR1 | |
| SCHEMBL6140977 | 0.81 | KMT2A (0.58) | LMNAARSMN1; SMN2CYP3A4NPSR1 | |
| SCHEMBL10664728 | 0.80 | CCR6 (0.64) | CYP3A4NPSR1TSHRCCR6HPN | |
| SCHEMBL10666460 | 0.80 | CCR6 (0.54) | LMNAARSMN1; SMN2CYP3A4NPSR1 | |
| SCHEMBL22288743 | 0.79 | AR (0.65) | LMNAARSMN1; SMN2CYP3A4NPSR1 | |
| SCHEMBL3188776 | 0.78 | ALDH1A1 (0.57) | LMNAARSMN1; SMN2CYP3A4NPSR1 | |
| SCHEMBL5922705 | 0.77 | LMNA (0.54) | LMNAARSMN1; SMN2CYP3A4NPSR1 | |
| SCHEMBL3194814 | 0.77 | LMNA (0.54) | LMNAARSMN1; SMN2CYP3A4NPSR1 | |
| SCHEMBL4026041 | 0.77 | AR (0.70) | LMNAARSMN1; SMN2CYP3A4NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861432-B2 | Piperazine derivatives that destabilize androgen receptors | SCHERING AKTIENGESELLSCHAFT (DE) | 2005-03-01 | — | — | US | disclosed |