Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502406 | 0.93 | HPGD (0.39) | LMNAMAPK1NLRP1HPGDTHRB | |
| SCHEMBL6504997 | 0.88 | TP53 (0.40) | THRBTP53PPARAALDH1A1MAPT | |
| SCHEMBL6496412 | 0.87 | PPARA (0.44) | LMNAMAPK1NLRP1HPGDTHRB | |
| SCHEMBL6494217 | 0.87 | S1PR3 (0.36) | THRBTP53PPARAMAPTPPARG | |
| SCHEMBL6505922 | 0.87 | CTSL (0.37) | LMNAMAPK1NLRP1HPGDTHRB | |
| SCHEMBL6494327 | 0.86 | EPHX2 (0.37) | LMNAHPGDTP53PPARAALDH1A1 | |
| SCHEMBL6495506 | 0.84 | PPARA (0.38) | LMNAMAPK1NLRP1HPGDTHRB | |
| SCHEMBL6494450 | 0.84 | PPARA (0.52) | PPARAPPARGPPARD | |
| SCHEMBL6494389 | 0.84 | PTGER4 (0.41) | LMNAMAPK1NLRP1THRBPOLB | |
| SCHEMBL6496468 | 0.82 | MAPT (0.38) | LMNAMAPK1NLRP1HPGDTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884821-B1 | Carboxylic acid derivatives and drugs containing the same | EISAI CO., LTD. (JP) | 2005-04-26 | — | — | US | disclosed |
| EP-1216980-A1 | CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME | Eisai Co., Ltd. (JP) | 2002-06-26 | — | — | EP | disclosed |