Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | MDM4 | O15151 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790102 | 0.79 | NPC1 (0.68) | MEN1KMT2AHPGDMAPTNPC1 | |
| SCHEMBL11099300 | 0.78 | PTPN1 (0.52) | MEN1KMT2AHPGDMAPTNPC1 | |
| SCHEMBL9621459 | 0.75 | MEN1 (0.82) | MEN1KMT2AHPGDMAPTNPC1 | |
| SCHEMBL11279358 | 0.74 | NPC1 (0.57) | MEN1KMT2AHPGDMAPTNPC1 | |
| SCHEMBL1110180 | 0.72 | MDM4 (0.73) | MEN1KMT2AHPGDMAPTNPC1 | |
| SCHEMBL24389088 | 0.72 | TP53 (0.72) | MEN1KMT2AHPGDMAPTNPC1 | |
| SCHEMBL4094232 | 0.72 | HDAC1 (0.72) | MEN1KMT2AHPGDMAPTNPC1 | |
| SCHEMBL29604506 | 0.72 | TP53 (0.72) | MEN1KMT2AHPGDMAPTNPC1 | |
| SCHEMBL7305489 | 0.72 | HPGD (0.72) | MEN1KMT2AHPGDMAPTNPC1 | |
| SCHEMBL3794850 | 0.72 | NPC1 (0.74) | MEN1KMT2AHPGDMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |