Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 7/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.72 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | MDM4 | O15151 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3790102 | 0.88 | NPC1 (0.68) | HDAC1HDAC3HDAC2MAPK1NPC1 | |
| SCHEMBL30363156 | 0.84 | HDAC1 (1.00) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL407834 | 0.84 | HDAC1 (1.00) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL7305489 | 0.83 | HPGD (0.72) | HDAC1HDAC3HDAC2MAPK1NPC1 | |
| SCHEMBL9621459 | 0.83 | MEN1 (0.82) | HDAC1HDAC3HDAC2MAPK1NPC1 | |
| Hydrochloric Acid SCHEMBL2828661 | 0.82 | HDAC1 (0.96) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL24389088 | 0.80 | TP53 (0.72) | HDAC1HDAC3HDAC2MAPK1NPC1 | |
| SCHEMBL29604506 | 0.80 | TP53 (0.72) | HDAC1HDAC3HDAC2MAPK1NPC1 | |
| SCHEMBL27527542 | 0.80 | HDAC2 (0.72) | HDAC1HDAC3HDAC2MAPK1NCOR2 | |
| SCHEMBL28773298 | 0.79 | MEN1 (0.57) | HDAC1HDAC3HDAC2MAPK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090203692-A1 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2009-08-13 | — | — | US | disclosed |
| EP-1885362-A2 | NOVEL CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006127458-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-11-30 | — | — | WO | disclosed |
| US-6432949-B1 | Amide derivatives useful as inhibitors of the production of cytokines | ASTRAZENECA AB (SE) | 2002-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203692-A1 | NOVEL CHEMICAL COMPOUNDS | HIPK3, HIPK1, HIPK4 | HDAC1 1549/4885HDAC3 1012/4885HDAC2 2038/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.