Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6498617 | 1.00 | KCNA5 (0.41) | KCNA5ALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL6336280 | 0.82 | KCNA5 (0.41) | KCNA5ALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL6336277 | 0.82 | KCNA5 (0.41) | KCNA5ALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL6500012 | 0.81 | MEN1 (0.39) | LMNAKDM4EKMT2AL3MBTL1MEN1 | |
| SCHEMBL6496976 | 0.80 | ALDH1A1 (0.41) | KCNA5ALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL6496972 | 0.80 | ALDH1A1 (0.41) | KCNA5ALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL6490324 | 0.78 | ALDH1A1 (0.38) | KCNA5ALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL6490321 | 0.78 | ALDH1A1 (0.38) | KCNA5ALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL6336255 | 0.75 | KCNA5 (0.40) | KCNA5ALDH1A1LMNASMN1; SMN2NPSR1 | |
| SCHEMBL6336259 | 0.75 | KCNA5 (0.40) | KCNA5ALDH1A1LMNASMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | ASTRAZENECA AB | 2005-12-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272745-A1 | Novel piperidine and piperazine derivatives | CYP3A5, IL5, ABCC5 | KCNA5 115/4885ALDH1A1 187/4885LMNA 3565/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.